منابع مشابه
Postaxial polydactyly in forelimbs of CRABP-II mutant mice.
The cytoplasmic retinoic acid (RA)-binding protein CRABP-II is expressed widely throughout early morphogenesis in mouse embryo, but its expression becomes more restricted as organogenesis progresses. CRABP-II expression remains strong in the developing limb bud suggesting a role for this protein in limb patterning. Here, we show that the CRABP-II promoter can direct expression of a lacZ transge...
متن کاملPolydactyly and ectopic ZPA formation in Alx-4 mutant mice.
Correct development of the limb is dependent on coordination between three distinct signaling centers. Recently, fibroblast growth factor-4 has been identified as a crucial determinant of AER function, which directs limb bud outgrowth, and Sonic hedgehog has been identified as a signaling molecule that mediates ZPA function, which specifies anterior-posterior patterning in the developing limb b...
متن کاملCyclophosphamide induced polydactyly in mice: understanding of underlying mechanism
Polydactyly with 6 or 7 digits bilaterally, or in all the four limbs at a time in certain cases was the principal finding amongst limb malformations in mice fetuses exposed to cyclophos-phamide in the dose of 10 mg /kg body weight on day 11 of gestation. Duplication of great toe was the most dominant. Augmentation of apoptosis by cyclophosphamide resulting in excessive programmed cell death in ...
متن کاملToe Polydactyly in Nigerian Boy
From Biblical days, the occurrence of six toes instead of five, called polydactyly, has been known. Of late, there have been some individual case reports from USA and Italy. Moreover, a group formed from several countries has dealt competently with genetic studies of 19 preaxial polydactyly families. Therefore, we report a case from Nigeria.
متن کاملBilateral Polydactyly in a foal
The following case report describes the diagnosis and surgery of bilateral polydactyly of unknown origin in a colt. A 7-month-old Berber colt was referred for cosmetic and curative excision of supernumerary digits. Radiographic examination revealed bilateral polydactyly and welldeveloped first carpal bones. Surgery consisted of an osteotomy of both second metacarpal bones combined with an amput...
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ژورنال
عنوان ژورنال: Nature
سال: 1950
ISSN: 0028-0836,1476-4687
DOI: 10.1038/165407a0